中山大学附属第五医院研究员，博士生导师，国家优青。2013年于加州大学洛杉矶分校获得博士学位，之后在斯坦福大学及俄勒冈健康与科学大学从事博士后训练。2017年9月以中山大学“百人计划”中青年杰出人才引进，并获得“广东省杰出青年医学人才”、“珠海市高层次人才（第三类）”和“中山大学优秀博士生导师”等称号。主要从事肿瘤免疫和血管相关疾病的研究，工作既注重发展基础理论，又紧密联系临床应用。任广东省转化医学学会心血管分会副主委，广东省精准医学应用学会老年慢病分会副主委，广东省医学会医学遗传分会委员，珠海市科学技术协会第七次代表大会代表，广东欧美同学会理事会理事, Journal of Leukocyte Biology 副主编，同时还是美国癌症研究协会（AACR）和美国女性科学者协会（Association for Women in Science）会员。

1.肿瘤微环境的单细胞转录组学研究；
2.脉管发育及相关疾病的多组学研究；
3.多种妇科疾病的致病机制探讨

在研科研项目：

1. 国家自然科学基金优秀青年科学基金项目， 2024/01-2026/12，主持

2. 国家自然科学基金重大研究计划培育项目，2022/01-2024/12，主持

已结题科研项目：

1. 广东省科技计划项目，2020/01-2021/12，主持

2. 国家自然科学基金面上项目，2019/01-2022/12，主持

3. 国家自然科学基金应急项目，2018/01-2018/12，主持

近期代表性论文

1. Haopei Zhang^#, Qiuyue Chen^#, Qianqian Zhang, Hairun Gan, Hanjie Li, Shoudeng Chen*, Hong Shan*, Pengfei Pang*, Huanhuan He*, DDX24 mutation alters NPM1 phase behavior and disrupts nucleolar homeostasis in vascular malformations, International Journal of Biological Sciences., 2023; 19(13): 4123-4138

2. YuJiao Gong^#, Yan Liang^#, Jie Liu^#, Jiaxing Wei^#, Shushan Zhang, Fangbin Chen, Qianqian Zhang, Lijie Wang, Huimin Lan, Wei Ge, Shuai Li*, Li Wang*, Hong Shan*, Huanhuan He*, DDX24 is essential for cell cycle regulation in vascular smooth muscle cells during vascular development via binding to FANCA mRNA, Arteriosclerosis Thrombosis and Vascular Biology., 2023, 43(9):1653-1667

3. Tianze Liu^#, Hairun Gan^#, Simeng He^#, Jia Deng^#, Xinyan Hu^#, Luting Li, Cai Li, Jianzhong He, Haoyu Long, Jianxun Cai, Hanjie Li, Qianqian Zhang, Lijie Wang, Fangbin Chen, Yuming Chen, Haopei Zhang, Jian Li, Lukun Yang, Ye Liu, Jianhua Yang, Dongming Kuang*,  Pengfei Pang*, Huanhuan He*, Hong Shan*, RNA helicase DDX24 stabilizes LAMB1 to promote hepatocellular carcinoma progression, Cancer Research., 2022, 82(17): 3074-3087

4. Famin Zeng^#, Yingwen Li^#, Zhaohua Deng^#, Jianzhong He^#, Wei Li, Lijie Wang, Ting Lyu, Zhanyu Li, Chaoming Mei, Meilin Yang, Yingying Dong, Guanmin Jiang, Xiaofeng Li, Xi Huang, Fei Xiao*, Ye Liu*, Hong Shan*, Huanhuan He*, SARS-CoV-2 spike spurs intestinal inflammation via VEGF production in enterocytes, EMBO Molecular Medicine., 2022, 14(5):e14844

5. Cuizan Cai, Xuxu Zhuang, Qi Zhu, Mingyue Wu, Huanxing Su, Xiaojin Wang, Iyaswamy Ashok, Zhenyu Yue, Qian Wang, Bin Zhang, Yu Xue, Jieqiong Tan, Min Li, Huanhuan He*, Jiahong Lu*, Enhancing autophagy maturation with CCZ1-MON1A complex alleviates neuropathology and memory defects in Alzheimer disease models, Theranostics., 2022, 12(4): 1738–1755

6. Shibo Zhang^#, Bingfan Xie^#, Lijie Wang^#, Hua Yang^#, Haopei Zhang, Yuming Chen, Feng Wang, Changqing Liu*, Huanhuan He*, Macrophage-mediated vascular permeability via VLA4/VCAM1 pathway dictates ascites development in ovarian cancer, The Journal of Clinical Investigation., 2021, 131(3):e140315

7. Yuan Wei, Chunxiang Huang, Xiao Xiao, Dongping Chen, Hong Shan*, Huanhuan He*, Dongming Kuang*, B cell heterogeneity, plasticity, and functional diversity in cancer microenvironments, Oncogene., 2021, 40(29):4737-4745

8. Pengfei Pang^#, Xiaojun Hu^#, Bin Zhou^#, Junjie Mao^#, Yu Liang, Zaibo Jiang, Mingsheng Huang, Ruihong Liu, Youyong Zhang, Jiesheng Qian, Jinsong Liu, Jinxin Xu, Yaqin Zhang, Maoheng Zu*, Yiming Wang*, Huanhuan He*, Hong Shan*, DDX24 mutations associated with malformations of major vessels to the viscera, Hepatology., 2019, 69(2):803-816

9. Huanhuan He, Julia J Mack, Esra Guc, Carmen M Warren, Mario Leonardo Squadrito, Witold W Kilarski, Caroline Baer, Ryan D Freshman, Austin I McDonald, Safiyyah Ziyad, Melody A Swartz, Michele De Palma, M Luisa Iruela-Arispe*, Perivascular macrophages limit permeability, Arterioscler Thromb Vasc Biol., 2016, 36(11): 2203-2212

2024年：国家优青

2023年：华夏医学科技奖“三等奖”

2022年：中山大学附属第五医院名医名师

2021年：中山大学优秀博士生导师

2020年：珠海市高层次人才（第三类）

2019年：广东省杰出青年医学人才

2017年：中山大学“百人计划”中青年杰出人才